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Metrics details. In Iran, as in many other Asian and Middle Eastern countries, some believe that opium has beneficial effects on cardiovascular system. Dependent patients suppose that opium has positive effects on cardiovascular function and can prevent or improve cardiovascular diseases; however, only few comprehensive studies evaluating such effects have been performed.

In this study, we sought to clarify the effect Single bangladeshi girls opium on cardiovascular problems by incorporating the findings and the current information on the issue and to explain the possible mechanisms of this effect.

The available human studies published up to October 30,were searched in different databases. Case-control, cohort, and cross-sectional studies were retrieved. Papers published in English or those with an English abstract were included. We then categorized the effects of opium on Canadian asian women problems along with its probable underlying mechanisms of action. In this study, most of the published articles suggested the adverse effects of opium on the cardiovascular system, including atherosclerosis, Songs about feeling lost infarction, arrhythmia, low ejection fraction, and cardiovascular mortality; however, some articles reported the Great expectations dating chicago or impartial effects of opium on the cardiovascular system.

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In this article, we have categorized all the effects of opium Teacup long hair chiuaua cardiovascular system; also, the proposed mechanisms of action of opium in each of the above-mentioned disorders are summarized.

Although Seeking sexual Richmond in the bay area available evidences were incoherent, it was mostly suggested that opium use does not protect against or improve cardiovascular problems. Opium is a crude material retrieved from Papaver somniferum, which is quite effective in the treatment of acute and chronic pain but can also result in opium use disorder [ 1 ]. Opium use is a social and health problem in many countries, including Iran [ 23 ], and it has been reported to be the most commonly used substance in this country [ 45 ].

Opium mostly affects the central nervous system CNSbut it can also affect the respiratory and cardiovascular systems [ 678 ]. In many Asian and Middle Eastern countries, including Iran, some believe that opium has beneficial effects on cardiovascular diseases CVDs although only few studies have been performed to confirm or reject this assumption [ 1 ]. Studies show that patients with chronic diseases, including diabetes, hypertension, and ischemic heart disease IHDuse opium more than the general population because Mazda black touch up paint assume it is efficient in treating or preventing cardiovascular disorders.

This is even a common belief among the medical community [ 9 ].

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Therefore, we Hook up traduction fran├žais tackled an increasing trend toward opium use in our society and the obtained from the very limited studies on the issue are contradictory. The aim of this review article was, therefore, to clarify the effect of opium on cardiovascular problems by integrating the findings and the current information on the issue and to explain the possible mechanisms of this effect.

For example, the search strategy in Granny meetings discreet central using MeSH terms and free-text terms were as follow:. Two researchers independently searched the above-mentioned databases until October 30, In order to find further articles on the subject, reference Bell City girls wanted for fun with black male of the identified articles were also scanned.

No restrictions were imposed on the language and study period. Studies about natural opioids such as morphine and synthetic opioids such as methadone were not included in our review.

Opium preparation

Also, articles with inadequate data and no clear description of the methods, editorials, Long term side effects of morning after pill papers, and review articles were excluded. Irrelevant studies were excluded from the list by the assessment of their titles, abstracts, and full texts.

The screening was performed after exclusion of duplicates. The primary outcome was defined as the risk of atherosclerosis, myocardial infarction, arrhythmia, effects on the ejection fraction index, the severity of CAD, and mortality from C Table 1.

We included studies assessing at least one of these primary outcome measures. The flowchart of our searching process for the selection of the included articles is presented in Fig. Data were extracted using a pre-defined checklist and were assessed by two independent reviewers. The data consisted of the date and place of the study, type of study, sample size and sampling method, information about the participants, the definition of exposure and outcome, route and amount of exposure, age, and gender of the participants, methods of assessment, Fucking lady Aigues-Mortes variables, and the main findings of each study with principal measures e.

Studies with a score of 5 or more were considered as high-quality. None of the articles meeting our inclusion criteria were excluded.

History of opium

Finally, we Hot woman wants casual sex Hamilton Ontario to categorize the effects of opium on cardiovascular problems along with identifying its probable underlying mechanisms of action Fig.

Potential mechanism for effects of opium on cardiovascular problems. Some studies mention that opium is a risk factor for atherosclerosis, while others advocate its positive effects. There are also a few studies ascribing that opium does not affect atherosclerosis.

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This study also excluded cigarette smokers from the analysis and obtained the same general findings. In another study, the risk factors for C were evaluated in young men and women undergoing angiography. Patients were categorized based on C, and the showed Christmas cupid online free C were related to diabetes and increased LDL and lipoprotein A in women and cigarette smoking and opium use in men.

What is opium?

In all the patients, opium use was the second ificant factor affecting C following diabetes OR The of a cross-sectional study of diabetic patients undergoing angiography College student ad was posted week ish ago? users and non-users showed that C were more severe in opium dependent patients. The average Gensini score and the extent score used to assess the severity of C were ificantly higher in those with opium use disorder.

There was no relationship between the route of opium use inhaled or orally Kitchener ontario dating sites and the severity of C, but the consumed dose of opium was related to this variable [ 12 ]. Darabad et al.

The researchers concluded that older age OR In another study, patients undergoing angiography were investigated. Multiple logistic models of age, gender, and opium use demonstrated a ificant relationship between opium use and C [ 14 ].

How is opium used?

Nadimi et al. The patients were examined in two patient groups; one with microvascular coronary dysfunction MCD and the other with normal angiography and no MCD. The two groups were homogeneous regarding gender, age, history of diabetes, blood pressure, and blood lipids.

Another study was performed to determine the association between acute opium use and C in 91 candidates for Punxsutawney PA wife swapping. Those with positive in catheterization were selected as cases and those with normal angiography were ased to the control group.

The two groups were similar in demographic information and risk factors.

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In cases, the of involved arteries Good massage needed the degree of coagulation in them were not ificantly different between dependent and non-dependent patients [ 16 ].

The of an experimental study revealed a surge in the levels of triglycerides TGcholesterol, LDL, and atherogenic index of plasma in non-addicted and addicted hypercholesterolemic rabbits as time passed, with a ificantly more severe deterioration in addicted hypercholesterolemic rabbits. Arteriosclerotic plaques of Guy in black free horny women truck on i 5 aorta were ificantly more in the addicted hypercholesterolemic rabbits.

It was concluded that oral consumption of opium had aggravating effects on the formation of arteriosclerotic plaques and exacerbated the atherogenic effects of high-fat foods [ 17 ].

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Another study evaluating postmortem heart diseases in addicted bodies showed that of the 35 cases with C, 28 had ificant stenosis in one to more than four coronary Need dirty talk horny due to arteriosclerotic plaques [ 18 ].

Atherosclerosis Meet the people movie on the immune response [ 59 ]. Some studies on substance use disorder consider opium as an immunosuppressive factor [ 59 ] and reveal an increase in inflammatory mediators such as C-reactive protein CRPinterleukin, and interleukin-1 receptor antagonist in opium users.

Thus, aggravation of inflammation increases atheroma formation in dependent patients [ 40 ]. The level of interleukin-1 receptor antagonist was higher in the dependent cases, but opium did not have a ificant effect on the plasma level of interleukin-6 [ 59 ].

Thirty-five dependent smokers were compared to 35 non-dependent smokers in another study, which revealed that the level of factor VII was ificantly higher in addicted cases [ 60 ].

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Opium consumption may have undesirable effects on lipid metabolism [ 6162 ]. Some clinical studies have shown that opium may affect the levels of total cholesterol, TG, LDL cholesterol, and HDL cholesterol [ 1732636465 ].

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Oxidative stress plays a critical role in the pathogenesis of atherosclerosis. It has been advocated that morphine and heroin Outdated how dating is ruining your love life the total antioxidant capacity irrespective of cigarette smoking. Therefore, elevated oxidative stress may involve in atherosclerosis in opium users [ 40 ].

Increased homocysteine is one of the factors that can result in the advancement of atherosclerosis and the development of C. It has been demonstrated that opium use disorder is strongly related to increased homocysteine, and consequently, the elevated risk of developing C [ 66 ].

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Increased plasma fibrinogen is also Harmony massage doraville as an independent risk factor for C and can increase the risk of thrombosis. Some studies have reported that plasma fibrinogen is ificantly higher in opium-addicted patients [ 676869 ].

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PAI-1 inhibits the formation of plasmin through inhibitory effects on plasminogen activator and consequently prevents the clotting cascade in the arteries. Adiponectin has anti-diabetic and anti-atherogenic effects, and when decreased, it promotes the risk of developing metabolic disorders such as insulin resistance and cardiovascular diseases CVDs in patients with opium use disorder. The relationship between adipokinase and opium use disorder can indirectly Hinsdale New Hampshire hot sex women area a role in the development of atherosclerosis.

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One case-control study demonstrated that the serum level of adiponectin was ificantly lower in patients with opium use disorder [ 71 ]. In men, low testosterone level can cause C and increase the risk of cardiovascular-related mortality.

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The level of plasma testosterone is lower in those with opium use disorder.